What over-the-counter medications are used to treat headaches?

Over-the-counter analgesics or pain-relieving medications for headaches include aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen (Advil, Motrin), naproxen (Naprosyn, Aleve), and acetaminophen (Tylenol).

In general, aspirin and NSAIDs are more effective for relieving headaches than is acetaminophen. Side effects are more common with aspirin, ibuprofen, and naproxen, especially stomach upset, bleeding, and dizziness. Many people use acetaminophen because they tolerate it better than aspirin, ibuprofen, or naproxen. People with a history of bleeding problems or stomach ulcers generally use acetaminophen. None of these pain-relieving medications should be used more than 2 days per week on average to avoid medication overuse or rebound headaches.