What over-the-counter medications can help treat carpal tunnel syndrome?

Nonsteroidal anti-inflammatory drugs (NSAIDs) can help treat the symptoms of carpal tunnel syndrome. These are over-the-counter drugs, like ibuprofen and aspirin, that can reduce pain and inflammation caused by carpal tunnel syndrome. Another treatment option that's available over-the-counter is a wrist splint. Splinting can help keep your wrist in a stable, neutral position, especially overnight.