What medications can interact with iodine supplements?

Amiodarone (Cordarone®) contains significant amounts of iodine. Plasma iodine levels may be increased and additive with iodine supplements. Thyroid function should be monitored.

Concomitant use of angiotensin-converting enzyme inhibitors (ACE-Is) or angiotensin receptor blockers (ARBs) with potassium iodide increases the risk of hyperkalemia (high blood potassium levels). Examples of ACE inhibitors include benazepril (Lotensin®), captopril (Capoten®), enalapril (Vasotec®), fosinopril (Monopril®), lisinopril (Prinivil®, Zestril®), moexipril (Univasc®), perindopril (Aceon®), quinapril (Accupril®), ramipril (Altace®), and trandolapril (Mavik®). The ARBs include losartan (Cozaar®), valsartan (Diovan®), irbesartan (Avapro®), candesartan (Atacand®), telmisartan (Micardis®), and eprosartan (Teveten®).

The use of pharmacologic doses of potassium iodide may decrease the anticoagulant effect of warfarin (Coumadin®).

Children with intestinal parasitic infestations treated with metronidazole have experienced reduced efficacy of oral supplementation with iodized ethyl esters by interfering with its absorption.

Perchlorate inhibits the uptake of iodide into the thyroid gland.

Additive hypothyroid effects may occur with the use of iodine products in combination with antithyroid drugs (methimazole, propylthiouracil).

Additive hypothyroid effects may occur with the use of iodine products such as potassium iodide in combination with lithium salts. Lugol solution can increase lithium toxicity by inducing additive hypothyroid effects.

Concomitant use of potassium iodide with potassium-sparing diuretics may increase the risk of hyperkalemia. Examples of potassium-sparing diuretics include spironolactone (Aldactone®), triamterene (Dyrenium®), and amiloride (Midamor®).

Iodine may also interact with antibiotics, anticancer agents, cardiovascular agents, neurologic agents, or thyroid hormones.

You should read product labels, and discuss all therapies with a qualified healthcare provider. Natural Standard information does not constitute medical advice, diagnosis, or treatment.