What medications can interact with aspartic acid?

Excessive intake of protein (aspartic acid is an amino acid) may lead to gout. Use cautiously in patients taking medications for the treatment of gout.

In a human study of young anorexic women, potassium aspartate supplementation had beneficial effects on the QT dispersion on an electrocardiogram. Aspartic acid may interact with cardiovascular drugs.

Magnesium aspartate supplementation may decrease blood pressure. Aspartic acid may add to the effects of blood pressure-lowering medications.

In human study, arginine aspartate decreased levels of total and LDL cholesterol. The effect of aspartic acid alone is unclear. Aspartic acid may add to the effects of cholesterol-lowering medications.

Aspartate salts may enhance aerobic performance. However, whether this is due to aspartic acid, arginine (also an amino acid), or the mineral, is not clear. Limited human research suggests that arginine aspartate may reduce plasma ammonia after exercise slightly, thus potentially reducing the purported fatigue-inducing effects of ammonia. However, research results are mixed. Aspartic acid may add to the effects of athletic performance enhancement agents.

Potassium and magnesium salts of aspartate may have fatigue-reducing effects. However, the effects of aspartic acid alone are unclear. Secondary reports suggest that aspartates may be low in individuals with chronic fatigue syndrome. Aspartic acid may add to the effects of CNS stimulant agents.

Based on secondary sources, increased calcium loss with a high-protein diet has been reported. Use cautiously in patients taking medications for osteoporosis.

Excessive intake of protein (aspartic acid is an amino acid) may lead to liver damage. Use cautiously in individuals with liver disorders or in those taking drugs that are toxic to the liver.

Excessive intake of protein (aspartic acid is an amino acid) may lead to kidney damage. Use cautiously in patients with kidney disorders or in those taking drugs that are toxic to the kidneys.

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