What is hypogonadotropic hypogonadism?
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Hypogonadotropic hypogonadism is a form of secondary hypogonadism. It is caused by the lack of two hormones, follicle stimulating hormone (FSH) and luteinizing hormone (LH), which stimulate production of the hormones testosterone and estrogen. These hormones are normally secreted by the pituitary, a gland in the brain regulated by the hypothalamus. A problem with either of these two brain centers can lead to hypogonadotropic hypogonadism. The condition affects pre-pubescent boys and girls and can lead to delayed puberty. Its cause is often linked to Kallmann syndrome, an inherited genetic defect.
Hypogonadotropic hypogonadism is a form of secondary hypogonadism. It is caused by the lack of two hormones, follicle stimulating hormone (FSH) and luteinizing hormone (LH), which stimulate production of the hormones testosterone and estrogen. These... More -
Dr. Natan Bar-Chama of The Mount Sinai Medical Center answered:Hypogonadotropic hypogonadism refers to the failure of the testicles to produce sperm due to a hypothalamic or pituitary disorder. It’s the cause of infertility in a small percent of patients and can exist at birth or be acquired. It’s also known as Kallmann's syndrome.
When hypogonadotropic hypogonadism is suspected, doctors usually order an MRI along with serum prolactin concentrations to rule out pituitary tumors. If levels of the prolactin are excessive but there is no mass, treatment will consist of lowering prolactin concentrations before proceeding with gonadotropin replacement therapy. During treatment, blood testosterone levels and semen analyses are obtained. Chances for pregnancy are excellent, since resultant sperm are essentially normal.
Hypogonadotropic hypogonadism refers to the failure of the testicles to produce sperm due to a hypothalamic or pituitary disorder. It’s the cause of infertility in a small percent of patients and can exist at birth or be acquired.... More
