What are the signs of primary hyperaldosteronism?

The most common sign of primary hyperaldosteronism is high blood pressure (hypertension) that does not respond to standard blood pressure medications. Patients with hypertension, especially resistant hypertension (blood pressure that is difficult to control and that requires multiple medications) should be tested for primary hyperaldosteronism. A low level of potassium in the blood (hypokalemia) is another sign, although patients with normal potassium levels may still have primary hyperaldosteronism. Low acidity of the blood (metabolic alkalosis) also is common.