What are side effects of histrelin subcutaneous implant?

Histrelin subcutaneous implant may cause a number of side effects. Some side effects include:

• smaller testicles
• warm feelings
• redness, infection, irritation or swelling at the injection site
• redness in the face, neck, arms or chest
• sweating

Histrelin subcutaneous implant may also cause decreased libido, constipation, flushing, headaches, impotence, insomnia, unusually warm skin and breast soreness in both genders, although these are less common. Contact your doctor about these side effects if they don't go away or interfere with your daily life.

Histrelin subcutaneous implant can also cause rare but more serious side effects, including:

• blood in the urine
• lowered urine output
• high blood pressure
• increased thirst
• appetite loss
• lower back or side pain
• nausea
• difficulty breathing
• fatigue
• weakness
• vomiting
• weight gain
• swelling in the face, fingers or lower legs

If you have any of these symptoms call your doctor right away.

If you have a severe allergic reaction, get emergency medical assistance or call 911. Severe allergic symptoms include:

• hives
• itching
• swelling of your tongue, throat, face
• difficulty breathing

Histrelin has also been found to cause liver damage, increase risk of heart attack in men and increase risk of developing diabetes.