Can primary-progressive multiple sclerosis cause other health issues?

Primary-progressive multiple sclerosis (PPMS) often leads to decreased mobility and may lead to other health issues as well. In the beginning stages of PPMS, most people will be able to go on with their lives unaffected, but as the disease progresses, it isn't uncommon to develop mental health issues like depression, anxiety, or mood swings. PPMS may also affect the functioning of your bladder, sexual organs, and digestive system.