How is juvenile osteoporosis different from osteogenesis imperfecta?

Although many of the symptoms of juvenile osteoporosis are similar to those of osteogenesis imperfecta (OI), the two conditions are completely unrelated. Both cause brittle bones in children. While osteoporosis usually resolves itself completely, OI is a very rare genetic disorder that never goes away during life. A child with OI will likely have a family history of the disorder, as well as whites of the eyes that are colored blue, purple, or gray in at least half of those affected. When a diagnosis is difficult, genetic testing or a bone biopsy may be required.