How are the MS drugs fampridine SR and 4-aminopyridine (4-AP) different?

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  1. Multiple Sclerosis Foundation
     
    Multiple Sclerosis Foundation answered:
    Fampridine SR, a drug used to treat multiple sclerosis-related gait disturbances, contains the same active ingredient as 4-aminopyridine (or 4AP), a medication that MS patients have been purchasing from compounding pharmacies for many years. Fampridine SR differs from 4-aminopyridine in how it is released in the body. Because Fampridine SR is a sustained-release product (hence the SR in the name) it has an increased duration of effect and does not have to be dosed as often as compounded 4-aminopyridine.
    More Related Answers from Multiple Sclerosis Foundation
    Fampridine SR, a drug used to treat multiple sclerosis-related gait disturbances, contains the same active ingredient as 4-aminopyridine (or 4AP), a medication that MS patients have been purchasing from compounding pharmacies for many years.... More