What is the rationale for taking high blood pressure medication at night?

The rationale for taking blood pressure medicine at night is multifactorial. One main reason is the following:There is a hormone axis known as the renin-angiotensin-aldosterone system that revs up at night and may lead to higher early morning blood pressures. This is the peak time when blood pressures are elevated due to these uncontrolled hormones that significantly increase your chances of stroke or heart attack. Taking blood pressure medicines at night allows for better control of this "hormone escalation" and keep blood pressures stable and thereby reduce cardiovascular complications.