Does dandelion interact with other medications?

Dandelion may interact with other medication, even though it is a natural herbal supplement. Dandelion interacts with medicines that treat diabetes or control blood sugar levels. These drugs include insulin, glipizide, glyburide, metformin, acarbose, and tolbutamide. Diuretics, or water pills also have a negative effect on dandelion, so do not take these while on dandelion.