Can sodium metabolism disorders have any complications?

Sodium metabolism disorders can lead to serious complications including comas, seizures, and death. In some cases, sodium concentrations in the blood can rise or fall rapidly, resulting in permanent brain damage. This can occur when the imbalanced sodium concentrations cause brain cells to expand or shrink rapidly, resulting in cellular death. In order to avoid the risk of brain damage, doctors must restore sodium levels to normal slowly - usually over a course of many days in severe cases.