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Ashley Koff, RD, Nutrition & Dietetics, answeredIn Dr. Mark Hyman's Ultrametabolism: The Simple Plan for Automatic Weight Loss, he calls for detoxifying the liver as a critical step to weight loss. His reasoning: a healthy functioning liver makes for a healthy functioning metabolism that can properly process foods. He underscores the fact toxins from both within our bodies and our environment can contribute to obesity. Hence, eliminating toxins and boosting your natural detoxification system is an essential component of long-term weight loss and a healthy metabolism.Helpful? 1 person found this helpful.