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Kent Holtorf, Endocrinology, Diabetes & Metabolism, answeredPhysicians are using human chorionic gonadotropin, known as HCG, to help individuals lose weight. Interestingly, this is not a new therapy. It was originally used for weight loss in the 1950's after a study demonstrated its effectiveness. There has been some controversy regarding its effectiveness because a few studies did not show significant benefit with its use, but a subsequent double-blind placebo controlled study found that, compared to placebo, the use of HCG resulted in significantly more weight loss, reduced appetite and improved the sense of well-being and energy. It has also been shown to be lipolytic (selectively reducing fat), producing a more healthy weight loss that spares muscle and boosts metabolism.Helpful? 4 people found this helpful.