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Honor Society of Nursing (STTI) answeredDuring week 22, you may want to consider scheduling an appointment to test for a protein called fetal fibronectin. This test, which involves taking and examining a sample from your amniotic sac, can help alert you if you are at risk for premature labor. Fetal fibronectin protein normally disappears from the amniotic sac for the period between the 22nd and 38th weeks of pregnancy. Women who continue to have the protein in their amniotic sac during that period are more likely to experience premature labor. Schedule an appointment to test for fetal fibronectin during week 22, then you can get tested and know as soon as possible whether this risk factor is a concern for you.