To work most effectively, we recommend our patients take 50 milligrams of hesperidin per day. It seems to work even more effectively in combination with another flavonoid called diosmin, which can be dosed at 450 milligrams a day. One study looked at over 5,000 people with vein problems like varicose veins and found those who took hesperidin and diosmin for 6 months had clear improvement.
While hesperidin may not completely get rid of the varicose veins that are already well established, it may help stop them from growing larger and will help prevent others from showing up. According to a study published in the International Journal of Gynecology and Obstetrics, hesperidin and diosmin was safe and effective in pregnancy, a time when women do tend to get varicose veins from the weight of the baby causing pressure on the veins coming from the legs.