Tongue spasm can be caused by a variety of factors. This condition may be caused by excessive activity in the parts of the brain that control muscle movement. Disorders that can cause tongue spasm include stroke, cerebral palsy, and multiple sclerosis. Certain antipsychotic drugs can also cause tongue spasm.
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Honor Society of Nursing (STTI) answered
RealAge answeredTongue spasms have a number of possible causes. Sometimes it's caused by a disorder such as cerebral palsy or multiple sclerosis or by nerve damage from a stroke. Movement disorders such as dystonia or Meige's syndrome, which cause involuntary muscle contractions and spasms, can also cause tongue spasms. Sometimes a tongue spasm is a side effect of certain antipsychotic drugs. The drug phochlorperazine (Compazine), which is used as an antipsychotic and also to treat severe nausea and vomiting, can cause tongue spasms.