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Thyroid-stimulating hormone deficiency means that the thyroid gland is not stimulated to make enough thyroid hormone, which is necessary for maintaining normal body metabolism. Because this hormone affects the function of so many bodily systems—nervous, digestive, endocrine, as well as the function of the heart, lungs, blood cells, bone and muscle, and response to stress, this hormone is necessary for life. Low thyroid, hypothyroidism, results in fatigue, weight gain, memory problems, constipation, cold-intolerance, hair loss, water retention and more.Helpful? 8 people found this helpful.