The use of monoamine oxidase inhibitors (MAOIs) has decreased with development of newer antidepressants that do not require diet modification. If a MAOI is prescribed, patients must strictly adhere to the tyramine-free diet throughout treatment and for an additional 2-4 weeks after the drug is discontinued.
Although the tyramine-free diet needs more long-term research to conclusively prove its benefits in patients suffering from migraine headaches, it is possible that some individuals may experience fewer migraine episodes when this diet is followed.
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