The granuloma annulare lesions may remain for a couple of years, then disappear, or reappear on another area. No one knows the cause of these lesions, but it is thought that they are a result of an immune-type reaction of the skin. Some doctors have speculated an association between granuloma annulare and diabetes, but such association has not been proven.
Granuloma annulare occurs more often in females than in males. The lesions are harmless and require no treatment unless there are cosmetic concerns. In such case, your doctor may consider injections of steroids into the lesions or treatment with liquid nitrogen. Topical creams are usually of little help.
It is important to have a physician confirm granuloma annulare, since other conditions, such as fungal infections, tick bite reactions and skin cancers can have a similar appearance and would require different treatment.