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Aurora Health Care answeredMohs micrographic surgery, a surgical treatment for several types of skin cancer, is an outpatient procedure, meaning you do not have to stay overnight in the hospital. The surgery typically takes from 1 to 10 hours, depending on the size of the tumor to be removed. Typically your surgeon uses a local anesthetic injected by needle into the surgical area. Your surgeon may suggest that you take a mild sedative to help you relax and feel calm during the procedure. Once the surgery is completed, your surgeon will close the wound using an approach that ensures the best outcome in healing and appearance.