If your sciatica is mild, you may find pain relief from over-the-counter medications like aspirin or acetaminophen. If over-the-counter medications don't provide adequate pain relief, your doctor may prescribe a more powerful medication like an anti-inflammatory drug or a muscle relaxant. For short-term symptom relief, your doctor may prescribe narcotics. In other cases, you doctor may recommend anticonvulsants or tricyclic antidepressants to ease your pain. If your sciatica needs a more aggressive treatment, your doctor may give you corticosteroid injections to reduce inflammation. Corticosteroids, however, cannot be used on a long-term basis.