Moderate or severe cases may require more firepower than mild cases. This could include prescription-strength topical steroids, or even injectable or oral immunosuppressive drugs. Examples of these include methotrexate, cyclosporine, alefacept, etanercept, and ustekinumab. These drugs are like linesmen on a football team. They block the action of specific immune cells and enzymes in your body that exacerbate psoriasis symptoms.