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Marc Garnick, Oncology, answeredBiochemical recurrence is a post-treatment increase in prostate-specific antigen (PSA) level, indicating that prostate cancer has recurred or spread following the original treatment for prostate cancer. It is also called biochemical failure. It can occur in up to 35% of men who have already received treatment with radical prostatectomy or radiation therapy. The only evidence of cancer recurrence in these men is an elevation of the PSA level.