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Proscar (dutasteride) may make the PSA test better. If you have a PSA that is going up, and we’re not sure if you have cancer or not, you’re going to get sequential PSA tests. If you go on Proscar or Avodart (finasteride) and if the PSA goes up, it’s probably much more likely that you have cancer than you don’t. So the drugs may actually help the PSA test to be a better predictor of whether you have cancer. Without the drugs, if the PSA goes up, it doesn’t necessarily mean that you have cancer, and many men have biopsies unnecessarily.Helpful? 1 person found this helpful.