In pancreatic cancer, cancer cells in the pancreas grow and multiply quickly, which can cause a tumor to grow. In stage 3 pancreatic cancer, a cancerous tumor has begun in the pancreas, and has spread beyond the pancreas into major blood vessels located near the pancreas. It may have also have spread to other parts of the body, especially organs and tissues found near the pancreas. The affect of this tumor on the body depends on where the tumor is, how it has spread, and how large it is. If the tumor blocks the flow of bile, which is produced in the liver, jaundice (a yellowing of the skin) may occur. If the tumor blocks parts of the digestive system, problems such as nausea, vomiting, and other digestive problems, may result. If the tumor spreads to areas of the body far from the pancreas, the cancer has advanced beyond stage 3.