Question

Ovarian Cancer

What is the role of IGFBP-3 in ovarian cancer?

A Answers (1)

  • ADavid Fishman, MD, Oncology, answered on behalf of The Mount Sinai Health System
    Insulin-like growth factor binding protein 3 (IGFBP-3) is involved in the suppression of mitogenesis and regulation of apoptosis. Forty-four percent of epithelial ovarian cancer showed methylation of this genes promoter region leading to a decreased detectable level of IGFBP in the serum. Overall survival was found to be associated with elevated levels of methylation. Additionally elevated levels are associated with early staged disease.
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What is the role of insulin-like growth factor (IGF) in ovarian cancer?