Ovarian Cancer

What is the role of IGFBP-3 in ovarian cancer?

A Answers (1)

  • ADavid Fishman, MD, Oncology, answered on behalf of The Mount Sinai Health System
    Insulin-like growth factor binding protein 3 (IGFBP-3) is involved in the suppression of mitogenesis and regulation of apoptosis. Forty-four percent of epithelial ovarian cancer showed methylation of this genes promoter region leading to a decreased detectable level of IGFBP in the serum. Overall survival was found to be associated with elevated levels of methylation. Additionally elevated levels are associated with early staged disease.
Did You See?  Close
What is the role of insulin-like growth factor (IGF) in ovarian cancer?