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Stacy Wiegman, PharmD, Pharmacy, answeredDon't drink alcohol if you're taking Dilaudid (hydromorphone). Doctors prescribe Dilaudid to relieve moderate to severe pain. Dilaudid belongs to a group of drugs called opioid analgesics. These drugs can cause a variety of side effects, including drowsiness and breathing problems. Combining Dilaudid with alcohol could exaggerate these effects and even be deadly.