Medications can be used to treat the symptoms of a deviated septum. Decongestants and antihistamines can be purchased at the drug store without a prescription and may help relieve your congestion and prevent runny noses. This could also help you avoid sinus infections. Many people find nasal sprays helpful as well, but there is a risk of becoming dependent on them so they should only be used in moderation. If your congestion is bad enough, your doctor might prescribe a cortisone nasal spray. These are stronger than the nasal sprays you can buy over the counter, but they come with the same risk of dependency so it is important to follow your doctor's instructions.