Ibuprofen should not be taken at the same time as aspirin, unless directed to do so by your doctor. Aspirin is another nonsteroidal anti-inflammatory drug (NSAID). To reduce the risk of damage to your gastrointestinal lining, avoid taking ibuprofen and drinking alcohol. Avoid taking ibuprofen if it is already an ingredient in another medication you are taking. Cough and cold medicines often contain ibuprofen. Always read your medications' labels for possible drug interactions and warnings about using ibuprofen. Avoid using ibuprofen if you are pregnant. Also avoid taking ibuprofen without first talking to your doctor if you have any of the following health conditions: heart disease, history of stroke, hypertension, edema, ulcers, asthma, liver or kidney disease, clotting disorder or nasal polyps.