The following drugs may interact with ibuprofen-diphenhydramine or raise the risk of certain side effects: anticoagulants, such as warfarin; aspirin; clopidogrel; corticosteroids such as prednisone; heparin; or SSRIs (selective serotonin reuptake inhibitors) like fluoxetine. Any of these may increase the risk of stomach bleeding. Interactions may also happen with MAOIs (monoamine oxidase inhibitors) such as phenelzine. This group of drugs can increase the risk of serious, irregular heartbeat. Use of ibuprofen-diphenhydramine may make ACE (angiotensin-converting enzyme) inhibitors, such as enalapril or diuretics, such as furosemide or hydrochlorothiazide, less effective. When taken with sodium oxybate (GHB), use of ibuprofen-diphenhydramine may make you sleep longer and decrease your ability to breathe properly. Use of ibuprofen-diphenhydramine with probenecid; beta-blockers such as propranolol; cyclosporine; lithium; methotrexate; or quinolones can increase the risk of certain side effects. Tell your doctor about all of the medicines, supplements or vitamins that you take (prescription or over-the-counter) as any drug has the possibility to interact with other medicines.