When taking ibuprofen-diphenhydramine avoid alcohol, other non-steroidal antiinflammatory drugs and other antihistamines or sedatives. The diphenhydramine component causes drowsiness. It should only be taken when you have time to devote to a full night's sleep. It could cause too much drowsiness if used in combination with other drugs or substances that have a sedative effect. You should also avoid sun exposure, as this drug may make your skin more sensitive to light and also make you more susceptible to heat stroke.