Other medications may increase the sleepiness caused by Astepro, making it unsafe to participate in certain activities, such as driving or operating equipment. Interactions with cimetidine (Tagamet) may cause an increased risk in side effects. Always consult your doctor before taking other medications with Astepro. Also, avoid alcoholic beverages while using Astepro. The interaction with alcohol may cause depression, impair thinking ability, and negatively affect psychomotor skills.