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Stacy Wiegman, PharmD, Pharmacy, answeredYou should not drink wine or any other alcoholic beverage while you're taking metformin (Glucophage, Fortamet), a prescription medication used to control blood sugar levels in people with type 2 diabetes. Alcohol lowers blood sugar and, while you're taking metformin, may increase your risk of a buildup of lactic acid. This buildup of lactic acid, known as lactic acidosis, can start slowly and get worse over time. In some cases, it can even cause death.