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International Bipolar Foundation answeredSome clinical trials for mood disorders have all participants take the experimental medication or undergo the experimental "talk therapy." Other clinical trials split the participants into two groups: those who take the medication or experience therapy and those who take a "placebo" or "sugar pill" or refrain from therapy. Throughout the trial, researchers continually evaluate participants, not only taking their own notes and measurements, but asking whether the participant is experiencing any changes in mood or side effects. Researchers may also need to execute laboratory tests, such as blood and urine tests.