Medications may be used in some cases to treat lentigo maligna melanoma either through chemotherapy or through other drug therapy options. In chemotherapy, strong drugs are given either orally or intravenously, and they work to kill cancer cells from the inside. Other types of medication may also be used to treat lentigo maligna melanoma in other ways. For example, imiquimod is a topical cream that may be applied to skin lesions to help destroy cancerous cells. Different treatments may be more or less effective for different people, so talk to your doctor about medication and treatment options.