Complications of systemic lupus erythematosus, or SLE, include damage to the kidneys and even kidney failure. Anemia and other blood problems, such as bleeding, blood clotting, or vessel inflammation, may develop. Pleurisy, or inflammation of the membrane around the lungs, can occur. SLE can affect the heart, leading to heart disease, atherosclerosis, inflammation of the heart muscle, membranes, or blood vessels, high blood pressure, and high blood cholesterol. Systemic lupus erythematosus can damage your central nervous system, leading to headaches, impaired thinking, hallucinations, personality changes, seizures, and psychoses. SLE can diminish the supply of blood to bones, leading to tissue death. If you have systemic lupus erythematosus, you are more likely to succumb to common infections and lymphatic cancers. If you are a woman, SLE can raise your risk of miscarriage and stillbirth.