The liver usually fails slowly with chronic conditions, but when we say "liver failure" we usually mean acute failure, which can happen in days. There are a number of conditions that can cause the liver to fail rapidly. Overdoses of acetaminophen is the most common, with prescriptions and even some herbal supplements also linked to liver failure. Besides toxins, the liver can fail from disease, including cancer and hepatitis. When your liver fails, it can leave you open to infections, cause bleeding problems, trigger kidney failure or cerebral edema - fluid in the brain. Treatment will likely be in the hospital. Medication and antitoxins can help in some cases, antibiotics if there are infections. Liver transplants are a standard treatment for many cases.