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National Academy of Sports Medicine answeredMaybe. Knee pain can have multiple causes, and therefore it is hard to say if focusing on one particular area will alleviate your knee pain. Research has shown that weakness in the gluteal (butt) muscles can also contribute to knee pain. While there are many contributing factors to knee pain, the most ideal and comprehensive approach to helping alleviate it [knee pain] is to implement a combined flexibility and strengthening program. This program should focus on your leg muscles' ability to decelerate, or slow your movements down and stabilize, which is your body's ability to keep your joints lined up in the right position(s). The following is a simple, sample exercise program you can incorporate as a warm-up before your existing exercise routine. First, foam roll (a form of self-massage that helps reduce muscle overactivity) the calves, outer thigh, inner thigh, and outer hip, finding at least one tender spot per body part and holding on each tender spot for at least 30 seconds. Second, static stretch the calves, inner thigh, and hip flexors (front of thigh), holding each stretch for approximately 30 seconds and repeating for a total of 1-3 repetitions. Next, activate some of the muscles that may have weakened in your hips and legs by performing the side-lying leg raise, ball bridge, and single-leg balance. Follow this with a ball squat and focus on moving at a slower tempo; perform this exercise for a total of 12-20 repetitions.Helpful? 2 people found this helpful.