Since intrinsic acute renal failure is usually the result of another serious condition, symptoms may be different depending on the cause of the kidney failure. Intrinsic acute renal failure can often be caused by an infection or allergic reaction to medication, or by a chronic kidney disease, so the symptoms of those conditions will usually be noticed first. The first symptom of intrinsic acute renal failure is often fluid retention, which leads to swelling or puffiness in the hands, feet, and legs. Some people will experience a decrease in their amount of urine, though this isn't the case with everyone. As the condition progresses, symptoms may include drowsiness, fatigue, and confusion. Other symptoms may include nausea, dizziness, loss of appetite, itchiness, and in severe cases, seizures.