Side effects of kidney cancer treatment may vary according to what treatment you receive. Before you undergo any kind of treatment, it's important to talk with your doctor about strategies for managing any side effects that may happen. Surgery may cause pain or discomfort at the site of the incision, and it can also lead to general fatigue and weakness. If biological therapy (immunotherapy) is used to treat kidney cancer, it may lead to nausea, vomiting, and fever. Radiation therapy may cause similar side effects, and may also affect cause the skin where it's used to become red and tender. Side effects of chemotherapy may include weakness, vomiting, loss of appetite, and hair loss. Side effects usually vary from person to person, but talk to your doctor if you have concerns about symptoms following your kidney cancer treatment.