Over time, high blood glucose levels can damage both blood vessels and nerves in your body. This can result in poor blood flow to your hands and feet in addition to your legs, arms, and vital organs. Poor blood flow to these areas increases your risk of infections, heart problems, stroke, blindness, foot or leg amputation, and kidney disease. In addition, you can either lose the feeling in your feet or have increased pain in your feet and legs. Damage to your feet can occur from mild injuries, and you may not know it. Finally, damage to blood vessels and nerves can lead to sexual problems that are difficult to treat. For all these reasons, you should make a major effort to avoid high blood glucose levels in your body.