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Deborah Serani, PsyD, Psychology, answeredProfound emotional sadness doesn't just weigh heavy on your mind. It significantly impacts your body. The depths of despair can lower your immune system, increase blood pressure and heart rate - and cause significant muscle weakness, just to name a few. Stress from grief can flood the body with hormones, specifically Cortisol, which causes that heavy-achy-feeling you get in your chest area.Helpful? 12 people found this helpful.