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Leo Galland, Integrative Medicine, answeredIt's well known that exercise burns calories. In addition, regular exercise stimulates the activity of fat-burning enzymes. The exciting news is that the hormone leptin also stimulates these enzymes, which can increase your metabolic rate even when you're not exercising. This is important because for most people, the resting metabolic rate accounts for two-thirds of the total number of calories they burn each day.Helpful? 1 person found this helpful.