Question

High Cholesterol

What are side effects of CholestOff for lowering cholesterol?

A Answers (2)

  • AMarcus Cox, MD, Cardiology, answered on behalf of Greenville Health System
    Nausea, heartburn, indigestion, constipation, or diarrhea may be potential side effects of CholestOff. These GI issues are typically minimal and are due to the fact of its competition with cholesterol in the gut. Also reported instances of erectile dysfunction and diminished sexual drive have been noted with CholestOff.

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  • AAnthony Komaroff, MD, Internal Medicine, answered
    The active ingredients in CholestOff are an amalgamation of sterols and stanols extracted from pine trees. The most common of these are beta-sitosterol, campesterol, and stigmasterol. Plant sterols and stanols help lower LDL (bad) cholesterol by blocking the absorption of cholesterol from food. This forces the body to draw LDL out of the bloodstream in order to extract its cholesterol to make bile acid and hormones.

    According to the latest national guidelines on cholesterol, eating two grams of plant sterols or stanols a day can lower LDL by 6% to 15%. You can get this amount from foods fortified with sterols and stanols, such as some brands of margarine, yogurt, orange juice, granola bars, and even tortilla chips. Or you can get it from supplements such as CholestOff—four caplets of CholestOff deliver 1.8 grams.

    A small body of research suggests that plant sterols (also called phytosterols) may protect against breast, prostate, and colon cancer. In the lab, plant sterols have been shown to slow or stop tumor growth, inhibit the spread (metastasis) of cancer, and cause cancer cells to self destruct. Keep in mind that this is preliminary research, and that what works in glass vials or plates doesn't necessarily work in the human body. That said, there isn't any evidence that consuming an extra two grams of plant sterols or stanols a day promotes breast or other cancers.

    Although plant sterols and stanols are "natural," a small percentage of people report bothersome side effects. These include nausea, heartburn or indigestion, constipation, diarrhea, and, in men, erectile dysfunction or decreased sex drive. If you are happy taking CholestOff and it is working for you, stick with it. But just so you know, a low-dose statin will lower your cholesterol just as well, if not better, and probably cost you less, with a similar risk of side effects.
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