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Mark Houston, MD, Internal Medicine, answeredRecent data suggest that it may be best to take most of your BP medications at night to prevent the usual rapid and high BP that occur in the early morning hours between 3 AM and 10 AM each day. This may also reduce the incidence of heart attack and stroke. All BP medications should have at least a 24 hour duration of action. Giving ACEI( angiotensin converting enzyme inhibitors, ARB( angiotensin receptor blockers) and calcium blockers drugs at night may be preferred. Giving diuretics in the morning is preferred to avoid nocturnal diuretic effects.Helpful? 2 people found this helpful.