Guillain-Barre syndrome is an aggressive disease that requires immediate medical attention to monitor progress. In the most acute phase, numbness can spread to the muscles near the lungs and heart and can lead to paralysis. If treatment is begun early, the risk of complications decreases. Less than 1% of people with Guillain-Barre syndrome experience complications, and even fewer die. Once Guillain-Barre syndrome goes into remission, life-expectancy doesn't seem to be affected.