The virus that causes genital herpes, herpes simplex type 2, can sometimes infect other areas of the body. Although uncommon, the herpes simplex virus can enter the skin through a cut in the fingers and cause pain and swelling. A genital infection might move up into your colon, causing difficulties in your gastrointestinal tract. The virus can also infect the brain, which can lead to seizures, disorientation, and even death. People with the skin condition eczema should avoid anyone with a herpes outbreak because it can lead to a serious skin infection.