The best thing you can do to treat your mold allergy is avoid breathing in mold spores. Unfortunately, it is unrealistic to expect to avoid an airborne allergen as common as mold, so your next best option is medication. Though medications can't prevent mold allergy, there's a wide variety of treatment options that will help relieve symptoms. Nasal sprays that contain antihistamines or corticosteroids can help treat inflammation, congestion, sneezing and runny nose. Antihistamines, decongestants, and montelukast can be taken by mouth to help relieve sneezing and a runny or stuffy nose. A course of allergy shots (immunotherapy) may help, but they're not as effective with mold allergy as they are with other types of allergies.